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The Eastern SC Heritage Region is designed to provide information about distinctive cultural sites and things to do near Myrtle Beach, things to do near Florence, things to do near I-95, as well as things to do near I-20. It includes these South Carolina counties: Chesterfield, Dillon, Florence, Darlington, Georgetown, Horry, Lee, Marion, Marlboro, Williamsburg.

Sites that fit at least one of the 7 themes and that are visitor-ready are called Certified Sites and are listed under the Special Places tab on this website.

The cultural or heritage themes are African American heritage, culinary heritage, nature-based tourism, agriculture and agritourism, military history, arts or architecture of the region, as well as racing heritage.